An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne.

نویسندگان

  • Christian Spiteri
  • Christopher Mason
  • Fengzhi Zhang
  • Dougal J Ritson
  • Pallavi Sharma
  • Steve Keeling
  • John E Moses
چکیده

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

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منابع مشابه

An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne.

An efficient synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reaction partners mediated by TBAF. Reactions are complete within 30 s, giving the target products in good to excellent yield.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 8 11  شماره 

صفحات  -

تاریخ انتشار 2010